My Malignant Melanoma

Seanty's experiences with Metastatic Malignant Melanoma. Part of Email us direct at

Thursday, 30 October 2008


Nature roundup

From the latest "Nature Reviews: Cancer", evidence that vitamin C is unhelpful for people taking chemo:

Nature Reviews Cancer 8, 830 (November 2008) | doi:10.1038/nrc2537

In the newsVitamin C: friend or foe?

Isobel Barry

Controversy has dogged the use of vitamin C supplements during cancer therapy, and research from the Memorial Sloan-Kettering Cancer Center has brought this once more into the public eye.

A preclinical study has shown that pretreatment of tumour cells with dehydroascorbic acid has a protective effect against a variety of anticancer agents — including imatinib, doxorubicin, cisplatin, vincristine and methotrexate — both in vitro and in mice. The work published in Cancer Research suggested that vitamin C inhibited drug-induced mitochondrial membrane depolarization. Speaking of his study, Dr Mark Heaney explained, "Vitamin C appears to protect the mitochondria from extensive damage, thus saving the cell" ( 1 Oct 2008). The build-up of the vitamin C within tumour cells could also be seen in those taking it in large supplemental doses, but the current work is yet to be extended to patients.

Dr Heaney emphasized that vitamin C is necessary in the diet but stated, "I don't recommend taking supplemental vitamin C during that period of time that my patients are receiving chemotherapy" ( 1 Oct 2008). The amounts of vitamin C used in the study were extremely high, but equivalent doses can be bought in health stores. Pamela Mason from the Health Supplements Information Service advised caution, recommending that anyone undergoing cancer treatment "seek the advice of their doctor or pharmacist before taking any product not prescribed by their doctor" ( 1 Oct 2008).

However, Dr Chi Van Dang from Johns Hopkins University emphasized that the possible beneficial effects of the molecule should not be forgotten: "Additional studies are necessary regarding whether vitamin C as a single agent could prevent cancer or the recurrence of cancer once treated" ( 1 Oct 2008).

In the British Journal of Cancer, a couple of diuretic drugs (amiloride and hydrochlorothiazide) are associated with an increased risk of Melanoma. Source.

Cancer Research UK predicts an increase in mortality from MM between now and 2025. Source.

Comments: Post a Comment

Subscribe to Post Comments [Atom]

<< Home


August 2008   September 2008   October 2008   November 2008   December 2008   January 2009   February 2009   April 2009   May 2009   June 2009   July 2009   August 2009   September 2009   October 2009   November 2009   December 2009   January 2010   February 2010   March 2010   April 2010   May 2010   June 2010   July 2010   August 2010   September 2010   October 2010   November 2010   December 2010   February 2011   March 2011   April 2011   May 2011   June 2011   July 2011   August 2011   September 2011   October 2011   November 2011   December 2011   January 2012   February 2012   March 2012   April 2012   May 2012   June 2012   July 2012   September 2012   November 2012   December 2012   January 2013   May 2013   June 2013   July 2013   August 2013   September 2013   October 2013   December 2013   July 2014   May 2015   July 2015  

This page is powered by Blogger. Isn't yours?

Subscribe to Posts [Atom]