My Malignant Melanoma

Seanty's experiences with Metastatic Malignant Melanoma. Part of Email us direct at

Friday, 26 March 2010


BRAF Inhibitors

I hear a rumour from fellow patients that GSK's "me-too" BRAF inhibitor is better than PLX4032. It seem that this is partly because of the account given by this MM patient as to the lack of a complete cure given by PLX4032.

I have heard a few other anecdotal accounts from patients on BRAF trials of this nature, but these do not contradict the previous trials at all. Only a very few people in the initial trials got a complete response. Whilst overall response was way higher than for the gold standard DTIC, this is a promising cancer drug. The very best cancer drugs we have for any cancer cure a tiny fraction, and give others a bit more time, ideally with a reasonable quality of life.

Back when I was diagnosed there was just DTIC, with its 15% response rate, and no chance of a cure. Now we may have a number of drugs with up to a 60% response rate and a small chance of a cure. Progress has seemingly been made.

We can't tell a thing from internet anecdotes in the meantime, other than the drugs aren't a complete bust so far. I can remember some promising-looking drugs which anecdotes made clear in short order were not going to hit the mark.

Labels: , ,

Comments: Post a Comment

Subscribe to Post Comments [Atom]

<< Home


August 2008   September 2008   October 2008   November 2008   December 2008   January 2009   February 2009   April 2009   May 2009   June 2009   July 2009   August 2009   September 2009   October 2009   November 2009   December 2009   January 2010   February 2010   March 2010   April 2010   May 2010   June 2010   July 2010   August 2010   September 2010   October 2010   November 2010   December 2010   February 2011   March 2011   April 2011   May 2011   June 2011   July 2011   August 2011   September 2011   October 2011   November 2011   December 2011   January 2012   February 2012   March 2012   April 2012   May 2012   June 2012   July 2012   September 2012   November 2012   December 2012   January 2013   May 2013   June 2013   July 2013   August 2013   September 2013   October 2013   December 2013   July 2014   May 2015   July 2015  

This page is powered by Blogger. Isn't yours?

Subscribe to Posts [Atom]